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Author

Brandon L. Tsai

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Oct 2026

A natural compound derivative targeting HADHA disrupts mitochondrial homeostasis and suppresses renal cell carcinoma.

Metastatic renal cell carcinoma (RCC) remains a lethal malignancy, and therapeutic resistance to current targeted and immune-based therapies highlights the need for new treatment strategies. Here, we identify C18-epi-brasilibactin A (CBA) as a selective inhibitor of RCC. High-throughput screening of a compound library...

Ara Jo, Sanjeevram Dhandapani, Zi-Qin Wang et al. · 0 citations
Jul 2026

DNMT3B drives neuroendocrine lineage plasticity and aggressive progression in prostate cancer.

It is demonstrated that DNMT3B is required for both the initiation and maintenance of the NEPC phenotype, and its inhibition suppresses NEPC growth and differentiation, highlighting it as a promising therapeutic target for treatment-resistant disease.

Yunsol Jo, H. Jung, Zi-Qin Wang et al. · 0 citations

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