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Brenda E. Porter

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Open access Sep 2026

mTORC1 drives cell-autonomous astrocyte reactivity in tuberous sclerosis.

Tuberous sclerosis complex (TSC) is a genetic neurodevelopmental disorder characterized by focal brain malformations called cortical tubers, which are associated with severe, intractable epilepsy1. Tubers are thought to result from somatic second-hit mutations that disrupt the TSC1 or TSC2 genes in neural progenitor ce...

Thomas L. Li, J. Blair, Taesun Yoo et al. · 1 citation

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