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Author

Brendan Frett

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Open access Aug 2026

Discovery of quinazoline-based dual RET/Aurora B inhibitors for non-small cell lung cancer.

RET and Aurora B (AurB) kinases play critical roles in tumor growth and survival in non-small cell lung cancer (NSCLC), yet monotherapy approaches are frequently undermined by acquired resistance and tumor heterogeneity. Here, we report the discovery of dual RET/AurB inhibitors with potent activity in NSCLC cells. Stru...

Maha Hanafi, Baha’a Jabali, Daniel Armstrong et al. · 0 citations

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