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Brennon Schofield

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Open access Jul 2026

Adenylosuccinate acts as a novel pro-angiogenic factor

We recently demonstrated a dramatic 77-fold increase in brain adenylosuccinate (AdSucc) concentration during ischemia, reaching ~0.56 mM levels. Previously, the role of AdSucc induction under decreased energy charge was attributed to the activation of purine nucleotide (PNC) and the tricarboxylic acid cycle (TCA). Howe...

Brennon Schofield, D. Seeger, Derek Besch et al. · 0 citations

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