Author

Brian C. Clark

2 papers indexed here

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Review Open access Sep 2026

Sarcopenia as a manifestation of systemic energetic failure with ageing.

Sarcopenia remains underdiagnosed and undertreated, partly because it continues to be mainly conceptualised as a disorder intrinsic to skeletal muscle. Although current definitions incorporate muscle strength and physical performance, they are not intended to explain the integrated physiological processes that underlie...

Luigi Ferrucci, S. Donegà, A. Picca et al. · The Lancet Healthy Longevity · 0 citations

Review Open access Aug 2026

Reframing sarcopenia as a disease of the ageing motor system.

Sarcopenia is a major driver of disability, frailty, and loss of independence in ageing populations. Current consensus definitions have shifted from low muscle mass to low muscle strength and impaired physical performance as the defining clinical features. The underlying disease model, however, has remained predominant...

L. B. R. Orssatto, W. D. Arnold, L. Ferrucci et al. · The Lancet Healthy Longevity · 1 citation