Open access
Aug 2026
JNK and p53 cause human and mouse β cell death during excessive unfolded protein response
In human β cells, pharmacological inhibition of both JNK and p53 improved β cell survival during GRP78 knockdown–induced UPR, and possible therapeutic targets to preserve insulin secretory capacity in diabetes are outlined.
Rohit B. Sharma, Christine O. Darko, Ying Wang et al.
· Journal of Clinical Investig... · 1 citation