Open access
Aug 2026
Single-cell multiome landscape reveals elovanoid-mediated suppression of inflammatory glial states and induction of homeostatic signaling after ischemic stroke.
ELV induced a phenotype shift from pro-inflammatory microglia, astrocytes, oligodendrocytes, oligodendrocytes, and OPCs in response to ischemic stroke damage, and upregulated gene pathways promoting synaptic integrity, reducing immune cell activation and neuronal loss.
Jeff X. Ji, Surjyadipta Bhattacharjee, Brian L. Giles et al.
· Experimental Neurology · 0 citations