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Author

Brian M. Hoffman

2 papers indexed here

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Sep 2026

EPR and ENDOR Characterization of Fe- and S-Ethylated [4Fe-4S]1+ Clusters, and a Cascade of H-Atom Abstractions Following Photolysis of the Fe–C Bond

Initiation of radical reactions by radical S-adenosyl-l-methionine (SAM) enzymes involves a central organometallic intermediate denoted Ω, with an Fe–C bond between the unique iron of a [4Fe-4S]3+ cluster and 5′C of 5′-dAdo. In some radical SAM (RS) enzyme processes, the 5′-dAdo moiety has been proposed to migrate fr...

Madeline B. Ho, Hyungdo Cho, Brittany N. Linn et al. · 0 citations
Open access Jul 2026

Thiooxazole Formation on a Nontypeable Haemophilus influenzae Virulence Factor Requires a Mixed-Valent Diiron Cofactor

The multinuclear nonheme iron-dependent oxidative enzyme (MNIO) family employs a multi-iron cofactor to catalyze a range of post-translational modifications (PTMs) in the biosynthesis of ribosomally synthesized, post-translationally modified peptide (RiPP) natural products. While significant progress has been made towa...

Olivia M. Manley, Madeline B. Ho, Patrick M. McLean et al. · 0 citations

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