Author

Brian McEllin

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Jul 2026

Abstract B096: Targeting NONO as a therapeutic strategy for metastatic castration-resistant prostate cancer (mCRPC)

A first-in-class strategy targeting the RNA-binding protein NONO using TF-Scan, a mass spectrometry–based functional proteomics platform that quantifies chromatin-associated protein networks in live cells, establishes NONO as a tractable target in mCRPC and introduces RNA molecular gluing as a novel modality to suppres...

Brian McEllin, D. Canzani, Lindsay K. Pino et al. · Clinical Cancer Research · 0 citations

Open access Aug 2026

Structure-free, site-resolved contrastive learning extends small-molecule discovery beyond the reach of structure-based modeling

Ptarmigan-1 is presented, a contrastive model that co-embeds the residues of a protein with candidate small molecules in a shared latent space, from sequence and two-dimensional chemistry alone, and without ever constructing a pose.

W. Fondrie, D. Canzani, L. Tatka et al. · bioRxiv · 1 citation