Author

Brian R. Isett

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Open access Sep 2026

Spatial transcriptomics reveals atorvastatin modulates the tumor microenvironment to suppress breast cancer liver metastatic outgrowth

Metastatic breast cancer remains incurable, underscoring the need for novel therapeutic strategies. Epidemiological and preclinical evidence suggests statins suppress metastatic outgrowth, however the underlying mechanisms remain unclear. We employed high-resolution spatial transcriptomics (ST) to explore the cellular...

Neha Atale, Jie Chen, Brian R. Isett et al. · Neoplasia · 0 citations

Review Open access Jul 2026

Multimodal AI in Tissue Diagnostics: Vision-Language Models and the Future of Computational Pathology.

Current pathology VLMs support a growing range of use cases, including image-text retrieval, label-efficient classification, visual question answering, abnormality localization, anomaly detection, report generation, and agentic workflow support, according to a review of current systems.

Rong Xia, Brian R. Isett, Jie Chen et al. · American Journal of Patholog... · 0 citations