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Brian Shuch

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Jul 2026

Abstract A060: Targeting metabolic–DNA repair vulnerabilities in SDHB- and FH-deficient renal cell carcinoma with the novel alkylating agent KL-50

Loss of the tricarboxylic acid (TCA) cycle enzymes succinate dehydrogenase B (SDHB) and fumarate hydratase (FH) in renal cell carcinoma (RCC) leads to accumulation of the oncometabolites succinate and fumarate, which impair homologous recombination (HR) repair through inhibition of KDM4A/B and aberrant H3K9 hypermeth...

Suparna M. Basu, R. Sundaram, Brian Shuch et al. · 0 citations

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