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Briana L. Sobecks-Doherty

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Open access Sep 2026

Mechanism of gating and isoform-specific inhibition in renal CLC chloride channels.

Hyponatremia is a prevalent disorder marked by excess water retention and substantial morbidity, motivating interest in the chloride channel CLC-Ka as a therapeutic target. Selectively inhibiting CLC-Ka without affecting the closely related CLC-Kb is essential for preventing serious side effects. However, developing is...

Chih-Ta Chien, Briana L. Sobecks-Doherty, A. Powers et al. · 0 citations

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