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Author

Brianna Corman

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Open access Aug 2026

Efficient experimental characterization of the GPCRome via deep receptor scanning

A versatile “deep receptor scanning” platform is introduced that can be used to experimentally characterize 766 human GPCRs and 174 known GPCR splice variants in parallel and show that many highly-expressed receptors exhibit systematic differences in hydrophobicity and secondary structure.

A. Tedman, Muskan Goel, Sohan S. Shah et al. · 0 citations
Open access Aug 2026

Translocon Remodeling Modulates Ribosomal Frameshifting and the Maturation of the Sindbis Virus Structural Polyprotein

The results indicate that −1PRF and spike protein maturation in alphaviruses is tuned by the dynamic remodeling of the ER translocon, which could allow polyprotein biogenesis to adapt to different stages of viral replication and to distinct host or vector environments.

Antonio Bonifasi, Gayani Apsara Ranasinghe, Ashish Jhangiani et al. · 0 citations

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