Open access
Sep 2026
Targeting hormone treatment for the brain in menopause
Estrogens are neuroprotective, and menopause may contribute to neurodegeneration. Estriol preferentially binds estrogen receptor beta (ERβ) in brain to induce neuroprotection. Previously, oral estriol improved cognitive processing speed and reduced cerebral cortex atrophy at treatment month twelve in women with multipl...
N. Itoh, Yuichiro Itoh, R. Patil et al.
· Scientific Reports · 0 citations