Heterologous expression of the Metarhizium anisopliae barc gene cluster reveals a diphenyl ether-to-xanthene transformation in barceloneic acid biosynthesis.
Filamentous fungi generate chemical diversity through several evolutionary strategies, including the elaboration of conserved biosynthetic intermediates into structurally distinct secondary metabolites. Emodin and its corresponding anthrone are central intermediates in fungal aromatic polyketide metabolism, yet the enz...