ABSTRACT Influenza B viruses contribute substantially to seasonal disease burden; however, the structural basis by which antibodies recognize the major glycoprotein hemagglutinin (HA) and mediate antiviral activity remains incompletely defined. Influenza B virus used to circulate as two antigenically distinct lineages,...
D. Bhavsar, Alesandro Civljak, Bruno Bonnettaz et al.· Journal of Virology· 0 citations
All living beings use ribosomes to synthesize proteins from α-amino acids. Inherited from our common ancestor, a few universally conserved ribosome biogenesis steps, introducing essential ribosomal RNA modifications, have survived to our days. However, it was unknown whether similar primordial core mechanisms could als...
Bruno Bonnettaz, Anna Smirnova, Marlène Vayssières et al.· bioRxiv· 0 citations
Together, these examples show that what antibody repertoires “see” is determined by the interplay between viral glycoprotein structure, B cell precursor availability, somatic evolution, and population‐level immunoglobulin diversity.
Bruno Bonnettaz, G. Bajic· Immunological Reviews· 0 citations
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