X-SPEAR: An Extensible Framework for Spatial Panel Evaluation and Refinement
Targeted spatial transcriptomics platforms such as 10x Genomics Xenium measure a predefined panel of genes. A gene is usually detected in fewer cells in the spatial assay than in the single-cell RNA sequencing (scRNA-seq) reference used to choose it, by an amount that differs from gene to gene. We present eXtensible Sp...