Author

Bunyamin Akgul

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Open access Jul 2026

METTL3 promotes cell-cycle progression via activation of transcriptional elongation.

Transcriptional elongation undergoes extensive remodeling at mitotic entry, yet how elongation control is integrated into core cell-cycle kinase networks remains unclear. Here, we identify the m6A methyltransferase METTL3 as a direct substrate of the mitotic kinase CDK1 in mammalian cells. CDK1-dependent phosphorylatio...

Azime Akçaöz-Alasar, Yanhua Wang, Hang Li et al. · Molecules and Cells · 1 citation

Open access Jul 2026

METTL3 modulates cell viability and motility in HCC1143 and MDA-MB-231 triple-negative breast cancer cells

The m6A methyltransferase METTL3 functions as a critical oncogenic driver in triple-negative breast cancer (TNBC). However, its specific downstream targets and mechanistic functions in less metastatic TNBC subtypes remain poorly characterized. To address this, we evaluated METTL3 expression and the phenotypic effects o...

Buket Sağlam-Şen, Azime Akçaöz-Alasar, Ahmet Batuhan Dondurur et al. · bioRxiv · 0 citations