Author

Burkard Becher

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Open access Sep 2026

Dendritic cell PD-L2 restrains intratumoral CD8+ T cell immunity

Blockade of inhibitory PD-1 signaling on T cells is a cornerstone of cancer immunotherapy, with current strategies targeting PD-1 or its ligand PD-L1. However, PD-1 engages an alternative ligand, PD-L2, whose role in tumor immunity remains poorly defined. Here, we show that PD-L2 is upregulated on intratumoral CCR7⁺ co...

Jinwoo Nah, Amanda Sun, Anushka Yadav et al. · bioRxiv · 0 citations

Open access Aug 2026

Altered follicular immunity in secondary lymphoid organs is associated with interferon hyperactivity in Down syndrome

Using multimodal single-cell and spatial profiling of human tonsils, extensive remodeling of immune organization in trisomy 21 is identified and identified as a unique human context to investigate how chronic interferon-associated inflammation reshapes lymphoid tissue organization and adaptive immune cell fate decision...

J. Dutto, Jeremías Bustos, Lucía Boffelli et al. · bioRxiv · 0 citations