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Author

Byungkuk Min

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Open access Sep 2026

N-terminal thrombospondin-1 enhances muscle function and tissue-specific metabolic adaptation in response to exercise and cold exposure

Exercise and cold exposure elicit partly overlapping metabolic adaptations through distinct mechanisms. Here, we sought to identify circulating factors shared by these stimuli. We found that exercise and cold exposure upregulated thrombospondin-1 (TSP1) expression in skeletal muscle and brown adipose tissue (BAT) and i...

M. Kim, Hyun-Jun Jang, Jae Sook Kang et al. · 0 citations
Open access Jul 2026

Splice-altering TP53 missense mutations as drivers of dysfunction and targets for RNA-based therapy.

A reclassification of select p53 mutations from simple missense to splicing-disruptive mutations reveals their underlying loss-of-function mechanisms and highlights their therapeutic reversibility, presenting a novel framework for RNA-based therapeutic strategies aimed at correcting splicing defects in TP53-mutant canc...

Sun-Ku Chung, Hangil Jung, Su-Jin Baek et al. · 0 citations

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