Lesion-Aware Adaptive Fourier Neural Operator for CT-to-PSMA PET Synthesis in Prostate Cancer
Deep learning models that synthesize PET from CT or MRI can reduce patient dose and scanner demand, but are typically optimized with global losses such as L1 or mean squared error (MSE) that treat all voxels similarly. In whole-body PSMA-PET, tumor voxels occupy only a small fraction of the volume, yet carry the clinic...