ABSTRACT Organoids are three‐dimensional multicellular structures derived from stem cells or primary tissues that recapitulate key structural and functional features of native organs. Advances in stem cell biology, biomaterials, and bioengineering have established organoids as powerful platforms for studying human deve...
Yue-Qi Leng, Yue Wang, C. Cao et al.· MedComm· 0 citations
Current knowledge of neuronal regulation in cancer across three layers is summarized: direct synaptic communication, neuron-derived paracrine signaling, and neuroimmune modulation, and a translational framework is proposed to bridge basic discoveries with clinical application.
Shiyi Liu, C. Cao, Chang Zhu et al.· Biochimica et biophysica act...· 0 citations
This review systematically examines the molecular and cellular determinants of drug response and resistance across 22 cancer types, highlighting key resistance mechanisms such as compensatory pathway activation, phenotypic plasticity, immune evasion, enhanced DNA damage repair, and the survival of drug-tolerant persist...
Xiaoxiao Cheng, Miao-Chun Xu, Juncheng Wei et al.· Signal Transduction and Targ...· 3 citations
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