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Open access Aug 2026

Phase 2 study of futibatinib in combination with pembrolizumab in patients with FGF19 expressing advanced hepatocellular carcinoma

Abstract Introduction Optimal treatment following first-line immunotherapy for advanced hepatocellular carcinoma (HCC) remains uncertain. This study evaluated futibatinib, a pan-FGFR inhibitor, combined with pembrolizumab in previously treated patients with FGF19-expressing HCC. Methods Eligible patients were ≥18 years...

Nguyen H. Tran, M. Palmer, Angela Ulrich et al. · 0 citations
Open access Aug 2026

Therapeutic targeting of cancer-associated fibroblasts with oncolytic virus in preclinical models of intrahepatic cholangiocarcinoma

Intrahepatic cholangiocarcinoma (iCCA) is an aggressive malignancy with limited effective therapies. Treatment resistance is partly due to activated cancer-associated fibroblasts (CAFs), which induce pro-tumor signaling and formation of a highly fibrotic tumor microenvironment. CAFs exist on a functional spectrum of su...

A. Abeynayake, T. Rengers, D. Carlson et al. · 0 citations

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