Cognitive changes in the asymptomatic stages of Alzheimer disease (AD) are subtle and difficult to detect using conventional cognitive tests. High‐frequency smartphone‐based testing may improve sensitivity to these changes, but generational differences in technology use could influence performance. We examined generati...
Samhita Katteri, Hannah M. Wilks, Matthew S. Welhaf et al.· Alzheimer's & Dementia· 0 citations
An APOE-independent polygenic risk score for Alzheimer’s disease derived from multiancestry GWAS summary statistics shows consistent associations with cognitive, imaging, biomarker and neuropathological features in diverse populations.
N. Kurniansyah, S. Tasaki, H. Rehman et al.· Nature Genetics· 0 citations
Findings identify widespread lncRNA dysregulation across neural cell types in the setting of a MAPT mutation and nominate the NORAD-pumilio axis as a regulatory pathway linking RNA homeostasis and tau propagation biology.
Joseph E. Zemke, Guangming Huang, Emma Starr et al.· bioRxiv· 0 citations
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