Alzheimer’s disease (AD) is a progressive neurodegenerative disorder affecting more than 55 million people worldwide and is characterized by cognitive decline, amyloid-beta (Aβ) plaques, and neurofibrillary tangles. Although transgenic rodent models have advanced understanding of AD, they do not fully replicate the spo...
Abdullatif Alsulami, Marika Bogdani, Evan L. MacLean et al.· npj Dementia· 0 citations
Results indicate α-synuclein clearance and propagation are mediated by glymphatic function and that aquaporin-4 mis-localization observed in the presence of human synucleinopathy may contribute to the development and propagation of Lewy body pathology in conditions such as Lewy body dementia and Parkinson's disease.
Molly Braun, Matthew J. Simon, Jay Jang et al.· Brain Communications· 0 citations
An approach that uses the collection of accumulated somatic mutations that uniquely labels each clone of cells to track the infiltration of bone-marrow-derived cells into the human brain finds evidence of an influx of bone-marrow-derived cells into the brain in all examined individuals.
Julia A. Belk, Yao-Wen Zhang, Emily E. Reilly et al.· Nature· 2 citations
This analysis identified a conserved newly formed differentiating (NFOL)/differentiating → lipid remodeling → Stress/ISR-reactive architecture, with a pronounced expansion of the Stress/ISR-reactive compartment and altered transition-associated pathway enrichment in high ADNC WM.
Joseph P. Voth, Javier Ramos Benitez, Angela M. Wilson et al.· bioRxiv· 0 citations
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