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Author

C. Davatzikos

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Open access Sep 2026

Sex-specific biological aging clocks across organs and omics.

Sex differentially shapes aging, neurodevelopment and neurodegenerative diseases such as Alzheimer's disease (AD). However, most biological aging clocks (artificial intelligence-predicted age minus chronological age) were trained on sex-pooled samples and implicitly assume sex invariance.Here we developed 38 sex-specif...

Zhi-Yuan Song, Derek Feng, Naowal Azraf Rahman et al. · 0 citations
Preprint Aug 2026

Auditable CT Phenotyping Through Report-derived Radiological Observations

Medical image foundation models can predict clinical phenotypes from computed tomography (CT), but strong performance leaves open whether they read disease-specific findings or shortcuts that correlate with the diagnosis. We tested this in 221 electronic-health-record (EHR) phenotypes using Auditable CT phenotyping (AC...

Riga Wu, W. Witschey, Yi-Cheng Li et al. · 0 citations
Open access Sep 2026

White matter hyperintensities and the structural connectome: a network perspective on clinical heterogeneity.

It is found that WMH are more strongly associated with RcSVD-related structural connectivity changes than with those implicated in dementia, suggesting that WMH may impact structural brain network through different pathways in RcSVD and dementia.

Bianca Mazini, Caio Seguin, Jing-Lei Lv et al. · 0 citations

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