Author

C. Dienemann

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Open access Aug 2026

Oriented binding of transcription factors to nucleosomes remodels chromatin at human promoters.

Transcription factors (TFs) can access nucleosomes via five distinct modes: gyre-spanning, periodic-binding, dyad-binding, and end-binding modes as well as an oriented binding mode, where the TF binding motif shows orientational preference relative to the nucleosome. Here, we report the first structure of an oriented T...

Tianyi Xiao, C. Crowe-McAuliffe, M. Ochmann et al. · Molecules and Cells · 0 citations

Open access Aug 2026

Kinase-specific phosphorylation of tau outside the amyloid core encodes fibril fold selection

It is demonstrated that kinase-specific phosphorylation outside the amyloid core can be sufficient to bias tau toward a defined fibril structure, establishing a direct mechanistic link between kinase specificity, post-translational modification, and tau strain formation.

Reshma Ramesh, Sambhasan Banerjee, Madhu Babu Gajula Balija et al. · bioRxiv · 0 citations