Author

C. Dillen

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Open access Oct 2026

Pan-Coronavirus Protease Engagement and Differentiated Pharmacology of Antiviral Candidate CMX990

COVID-19 highlighted the need for antivirals that can be rapidly deployed against both current and future coronavirus threats. CMX990 is a clinical stage coronavirus main protease (Mpro) inhibitor bearing a unique trifluoromethoxymethyl ketone warhead. Here, we broadly evaluate its pan-coronavirus target engagement, an...

N. G. R. Dayan Elshan, Karen C. Wolff, L. Riva et al. · bioRxiv · 0 citations

Open access Sep 2026

Allergic Airway Inflammation Protects Against SARS-CoV-2 and MERS-CoV Disease but Promotes Fatal SARS-CoV-1 Immunopathology

Epidemiological, clinical, and experimental data suggest that allergic asthma may have protective effects against severe Coronavirus Disease 2019 (COVID- 19) but are often conflicting between different models of infection and epidemiological analyses. Allergic asthma is characterized by type 2 (T2) inflammation, mucus...

J. Ardanuy, Grace Garrett, C. Dillen et al. · bioRxiv · 0 citations