Author

C. Evelo

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Preprint Sep 2026

Making Models That Matter: How to Build Trustworthy and Useful Systems Biology Models

Computational models supporting mechanistic understanding of (complex) biological systems, systems behaviour prediction, and experimental design are becoming more and more embedded in research on complex biological systems. Reuse and refinement of models, rather than continuous reinvention, is becoming increasingly imp...

John M. Hancock, Mihail Anton, Frank T. Bergmann et al. · 0 citations

Open access Jul 2026

Integrating transcriptomics and molecular AOPs to identify T3-dependent regulation of neuronal development in the human neural progenitor test.

It is demonstrated that absence of T3 inhibits brain development since no T3 condition affects key neurodevelopmental processes in vitro, illustrating the utility of integrating transcriptomics with molecular AOPs to provide a structured, mechanistic framework for evaluating the regulation of neuronal cell proliferatio...

Marvin Martens, N. Dierichs, J. L. Pennings et al. · Toxicology · 0 citations

Open access Aug 2026

Network-based stratification of allele-specific expression reveals patient subgroups in Huntington’s disease

By propagating gene-level ASE imbalance profiles through a protein-protein interaction network, 20 HD patients are stratified into three distinct biological patient subgroups, highlighting neuroinflammatory pathways as key sources of inter-patient heterogeneity and transcriptional regulatory variation as a potential co...

D. van Beek, Aishwarya Iyer, Friederike Ehrhart et al. · Bioinformatics · 0 citations