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C.-F. Hsu

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Open access Sep 2026

209. Early adversity, social support, and loneliness in bipolar disorder: the distinct role of psychotic features

Abstract Background Loneliness is a major determinant of mental health and has been increasingly recognized as a critical transdiagnostic factor contributing to illness burden, suicidality, and impaired psychosocial functioning in bipolar disorder (BD). Early adversity is strongly linked to mood dysregulation, social i...

Sp Konara Mudiyanselage, C.-M. Wang, W. Chang et al. · 0 citations
Open access Sep 2026

191. Loneliness, social cognition, and psychotic features in bipolar disorder: the mediating role of social support

Abstract Background Bipolar disorder (BD) is associated with persistent interpersonal difficulties, social cognition impairment, and elevated loneliness even during euthymic periods. Individuals with BD who present with psychotic features (BD-P) often demonstrate more severe neurocognitive and functional impairment tha...

S. Mudiyanselage, C.-M. Wang, W. Chang et al. · 0 citations
Open access Sep 2026

110. Glutamatergic changes in the medial prefrontal cortex associated with psychosis history in bipolar disorder and their relationship to executive function

Elevated mPFC Glu and Glx in BD-P suggest that localized glutamatergic hyperactivity may underlie psychotic experience of BD, and the negative association between mPFC E/I ratio and cognitive flexibility observed only in BD-NP indicates that glutamatergic regulation of executive function differs by psychosis history.

C.-Y. Chang, C.-Y. Wu, S.-Y. Wei et al. · 0 citations

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