Abstract Background Loneliness is a major determinant of mental health and has been increasingly recognized as a critical transdiagnostic factor contributing to illness burden, suicidality, and impaired psychosocial functioning in bipolar disorder (BD). Early adversity is strongly linked to mood dysregulation, social i...
Sp Konara Mudiyanselage, C.-M. Wang, W. Chang et al.· International Journal of Neu...· 0 citations
Abstract Background Bipolar disorder (BD) is associated with persistent interpersonal difficulties, social cognition impairment, and elevated loneliness even during euthymic periods. Individuals with BD who present with psychotic features (BD-P) often demonstrate more severe neurocognitive and functional impairment tha...
S. Mudiyanselage, C.-M. Wang, W. Chang et al.· International Journal of Neu...· 0 citations
Elevated mPFC Glu and Glx in BD-P suggest that localized glutamatergic hyperactivity may underlie psychotic experience of BD, and the negative association between mPFC E/I ratio and cognitive flexibility observed only in BD-NP indicates that glutamatergic regulation of executive function differs by psychosis history.
C.-Y. Chang, C.-Y. Wu, S.-Y. Wei et al.· International Journal of Neu...· 0 citations
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