AIMS
Fibroblasts are mesenchymal cells in the healthy vascular adventitia. In atherosclerosis, single-cell sequencing datasets suggest fibroblasts are abundant in plaques. However, their identity, origin, and fate during plaque progression remain unclear, which we aim to unravel here.
APPROACH AND RESULTS
To robustly...
Guan-Liang Li, S. Asselberghs, Bai-Xue Yu et al.· Cardiovascular Research· 0 citations
This review compares convolutional, Transformer-based and graph architectures used to represent local sequence features, chromatin state and three-dimensional genome organisation to their applications to transcription-factor binding, chromatin accessibility, gene expression, non-coding variant prioritisation and regula...