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Author

C. Fernandes

2 papers indexed here

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Open access Oct 2026

Antibacterial activity and mechanistic insights into para-substituted triphenylphosphonium salts.

Dodecyl- and tetradecyl-substituted triphenylphosphonium (TPP) derivatives (1d and 1e) were previously identified by our group as potent antimicrobials, although their mammalian cytotoxicity and hemolytic activity limited their therapeutic potential. To mitigate these drawbacks, six novel para-substituted TPP derivativ...

Bárbara Nunes, F. Cagide, Anna C. Vetter et al. · 0 citations
Oct 2026

Dual inhibitors of SARS-CoV-2 Nsp13 helicase functions with broad anti-hCoV activity and combination effects with approved antivirals.

The SARS-CoV-2 non-structural protein 13 (nsp13) is a highly conserved helicase essential for viral replication and immune evasion. Its conservation across coronaviruses makes it an attractive target for the development of broad-spectrum antiviral agents. Hence, we rationally designed and synthesised 42 novel 2-iminoth...

Erica Sanna, A. Corona, S. Distinto et al. · 0 citations

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