Effects of withdrawal from intermittent vs. long access cocaine self-administration on nucleus accumbens calcium permeable AMPA receptor transmission and incubation of craving in female and male rats.
RATIONALE Following the discontinuation of long access (LgA) to cocaine self-administration rats show a time-dependent increase in motivation for drug ("incubation of craving") thought to be mediated by enhancements in transmission via nucleus accumbens (NAc) calcium-permeable AMPA receptors (CP-AMPARs). Intermittent a...