Author

C. Floudas

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Review Oct 2026

Immune checkpoint inhibitors in platinum-resistant ovarian cancer: Clinical disappointments, biological lessons, and the reopening of therapeutic opportunities.

Immune checkpoint inhibitors (ICIs) have transformed the treatment landscape of several malignancies; however, their efficacy in platinum-resistant ovarian cancer (PROC) remains limited. The immunosuppressive tumor microenvironment (TME) in ovarian cancer constitutes a major barrier to effective antitumor immunity, pro...

E. Giudice, A. Spinazzola, C. Floudas et al. · Cancer Treatment Reviews · 0 citations

Open access Sep 2026

Early termination of clinical trials enrolling patients with breast cancer: Reasons, determinants, and temporal patterns

Background The occurrence of clinical trial termination before planned completion (or “early termination” [ET]) remains poorly characterized in the breast cancer field. This study investigates the reasons, determinants, and temporal patterns of ET in breast cancer trials. Methods We conducted a cross-sectional study us...

G. M. Iannantuono, G. Daniele, Luca Mastrantoni et al. · Breast · 0 citations

#artificial intelligence Review Sep 2026

Towards AI-Assisted Clinical Trial Matching: Practical Considerations, Multicenter Evaluation, and Real-World Deployment

TrialGPT 2.0 is presented, an AI-assisted clinical trial recommendation system designed for real-world deployment that improves clinician efficiency and identifying frequently overlooked trial opportunities, ultimately helping to expand and accelerate accrual to cancer trials.

Yin Fang, Qiao Jin, Shubo Tian et al. · 0 citations