Nanoparticles encapsulating therapeutic RNA have emerged as a transformative strategy in precision medicine, enabling a wide range of applications such as gene therapy for rare diseases, the silencing of toxic gene products, and the mobilization of the immune system to induce specific responses ranging from immune tole...
V. Stamenković, Mislav Brajković, Coral García-Fernández et al.· ACS Biomaterials Science & E...· 0 citations
Small extracellular vesicles (sEVs) are emerging as promising nanocarriers for non-invasive pulmonary drug delivery, yet their effectiveness is limited by sequential barriers imposed by airway mucus and the pulmonary epithelium-endothelium interface. Here, we investigated how post-secretory surface engineering with exo...
Maria José Sanchez, P. Leivar, Soraia Pinto et al.· Materials Today Bio· 0 citations
The findings indicate that the proposed formulation PEPB - the oncolytic adenovirus AdNuPARc-E site-specifically shielded with OM-PBAE-CRRR/PEG - offers a promising approach to improve tumor targeting after systemic administration, even in the presence of pre-existing neutralizing antibodies.
Marc Otero-Mateo, Francesc Estrany, Daniel Pembaur et al.· Journal of Controlled Releas...· 0 citations
Findings indicate that genetically determined short sleep duration and insomnia symptoms are associated with mental and neurological problems, cardiovascular disease and musculoskeletal disorders, suggesting a potentially preventive, causal role of healthy sleeping patterns on chronic disease.
Marta H Hernandez, C. Lassale, A. Camps-Vilaró et al.· Journal of Sleep Research· 0 citations
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