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Author

C. Fraza

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Preprint Oct 2026

Transferable conditional brain charts link cortico-subcortical structure to Alzheimer's disease progression

Normative models chart how brain measures vary across the lifespan, expressing each individual as a deviation from a healthy reference. However, most regional models of cortical thickness disregard dependencies between cortical and subcortical anatomy, and transferring them to a new site typically requires retraining o...

Nitin Sharma, Si-Cheng Dai, F. Mallus et al. · 0 citations
Open access Oct 2026

Structured missingness in biomedical research

It is shown that many popular imputation algorithms systematically fail under structured missingness, distorting the underlying statistical properties of the data in ways that conventional accuracy metrics cannot detect.

B. Bučková, C. Fraza, C. Lemvigh et al. · 0 citations
Review Jul 2026

The Coupled Stochastic Dynamical System: A Generative Model for Simulating and Forecasting Youth Mental Health Trajectories

The Coupled Stochastic Dynamical System is introduced, a forward generative model that jointly simulates digital engagement, weara-ble physiology, and psychiatric burden as a family of coupled stochastic processes and position generative behaviour-al models as falsifiable and interpretable frameworks for studying youth...

N. Koutsouleris, G. Turner, N. Penzel et al. · 0 citations

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