Author

C. García-Delgado

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Open access Aug 2026

The red box: a selective G-quadruplex binder that downregulates c-MYC expression in human cells

Unlike previously reported G4-selective ligands based on Pd(ii)/Pt(ii) metallacycles, the red box achieves nanomolar affinity and selectivity through a fully metal-free, hydrazone-based scaffold, addressing key limitations related to cost, biodegradability, and long-term biocompatibility.

Paula Novo, Iván Montes de Oca, C. García-Delgado et al. · RSC Chemical Biology · 0 citations