From Pathogenesis to Therapy: Extracellular Vesicles Orchestrate Cellular Crosstalk in Acetaminophen Hepatotoxicity.
Drug-induced liver injury (DILI) is a major cause of acute liver failure, with acetaminophen (APAP) overdose representing the leading cause of intrinsic hepatotoxicity worldwide. Although the mechanisms of APAP-induced liver injury have been extensively characterized, recent evidence highlights a critical role for extr...