Author

C. Giles

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Open access Oct 2026

Polygenic risk scores for hypertensive disorders of pregnancy and later-life cardiovascular disease in women

Objectives: To investigate whether genetic predisposition to hypertensive disorders of pregnancy (HDP), measured using polygenic risk scores (PRS), is associated with subsequent cardiovascular disease (CVD) outcomes in analyses stratified by HDP history. Study design and main outcome measures: This population-based coh...

G. Krishnamurthy, J. A. Temple, M. A. Ahmed et al. · medRxiv · 0 citations

Open access Aug 2026

Integration of lipidomic and polygenic risk scores within contemporary clinical cardiovascular risk assessment pathways: a multi-cohort development and validation study

This investigation investigated whether selective integration of lipidomic and genomic risk signals into AusCVDRisk improves 5-year CVD prediction and reclassification, with a focus on individuals at intermediate clinical risk.

Aleksandar Dakic, Jing-Qin Wu, Ting-Ting Wang et al. · EClinicalMedicine · 0 citations

Open access Aug 2026

Multi-omic characterization of the Hispanic/Latino blood lipidome reveals an additional locus and attenuated genetic prediction.

A lipidome-wide GWAS of 830 lipid species in 2,287 Hispanic/Latino participants and predictive modeling across omics layers provided a genetic landscape of lipid metabolism in a highly burdened population and highlights the challenges in predicting lipid abundance.

Wanying Zhu, Hung-Hsin Chen, H. Highland et al. · HGG advances · 0 citations