Open access
Oct 2026
Inhibition of endogenous TGF-β normalizes extracellular matrix deposition in hiPSC-derived fibroblasts
It is shown that iPSC-derived fibroblasts (F-hiPSC) exhibit enhanced proliferative capacity and substantial functional differences compared to primary fibroblasts, and the potential of modulating TGF-β signaling to normalize F-hiPSC ECM production is unraveled.
L. Guillot, L. Jobeili, Léa Cassulino et al.
· npj Regenerative Medicine · 0 citations