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C. Heim

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Open access Aug 2026

Cereblon on Steroids: Beyond the Canonical Ligand Space

Cereblon (CRBN) is widely used in targeted protein degradation, but its ligand space has remained dominated by a narrow set of cyclic imide chemotypes. Here, we show that the accessible CRBN ligand space extends substantially beyond this canonical space. A high-throughput screen of > 40,000 compounds, followed by ortho...

Alexander Herrmann, C. Heim, Samuel A. Maiwald et al. · 0 citations

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