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Review Sep 2026

Harnessing novel agents to target KRAS-driven pathways in pancreatic cancer.

INTRODUCTION Pancreatic ductal adenocarcinoma (PDAC) is an aggressive malignancy in which activating KRAS mutations, present in more than 90% of tumors, constitute the principal oncogenic driver. Advances in structural biology have enabled the pharmacologic targeting of KRAS, a protein historically regarded as 'undrugg...

Joanna Kreidi, C. Hoyek, C. Eslinger et al. · 0 citations

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