Introduction/ Objective: Rheumatoid Arthritis (RA) is an autoimmune disease characterized by chronic inflammation of the synovial joints, leading to joint destruction and systemic complications. Existing therapies, such as Disease-Modifying Antirheumatic Drugs (DMARDs) and Nonsteroidal Anti-Inflammatory Drugs (NSAIDs),...
Ashok Thulluru, C. Jangme, Vrushabh Patil· Recent Advances in Drug Deli...· 0 citations
INTRODUCTION/OBJECTIVE
Multidrug Resistance (MDR) remains a major obstacle to effective cancer chemotherapy, driven by multiple interconnected mechanisms, including overexpression of ATP-binding Cassette (ABC) transporters, enhanced DNA repair, apoptosis evasion, and protumorigenic microenvironmental factors. Heat Shoc...
Sundeep Kadasi, A. Kholkumbe, C. Jangme et al.· Mini-Reviews in Medical Chem...· 0 citations
Advances establish PROTAC technology as a transformative platform in modern drug discovery while emphasizing the scientific and translational challenges that must be addressed to enable broader clinical application.
S. Badadhe, Vikas B. Gawali, Mahesh D. Bhalsing et al.· Discover Chemistry· 0 citations
Combined computational and preliminary cell-based findings support compound 4i as a promising lead for further investigation of EGFR-targeted anticancer activity and biochemical EGFR kinase inhibition and target-engagement studies are required to determine the mechanism of action.
S. Badadhe, Vikas B. Gawali, C. Jangme et al.· Journal of the Iranian Chemi...· 0 citations
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