Open access
Sep 2026
Cardiomyocyte-specific loss of Smyd5 leads to a robust activation of inflammatory signaling and heart failure in mice
Background Cardiomyocytes respond to stress by undergoing hypertrophic growth driven by dynamic changes in gene expression. Epigenetic mechanisms, including histone methylation, play critical roles in regulating these transcriptional programs, yet the enzymes controlling these modifications during cardiac disease remai...
R. Bia, Samuel M. Hickenlooper, Mickey R. Miller et al.
· bioRxiv · 0 citations