Author

C. L. de Brito Magalhães

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Open access Aug 2026

Identification of 4-Amino-7-chloroquinoline Derivative with In Vitro Activity Against Chikungunya Virus

Among the tested compounds, derivative 6 demonstrated the most pronounced anti-CHIKV activity, with a low micromolar effective concentration and moderate selectivity index, and was identified as a potential lead candidate for further development against CHIKV.

A. C. C. Reis, Camila Portruneli, L. da Cunha Agostini et al. · Current Microbiology · 0 citations

Open access Jul 2026

Evaluation of the Antiviral Activity of Monomeric, Dimeric, and Oligomeric Flavonoids against Chikungunya and Mayaro Viruses

Results identify PC1 as the most promising candidate for future preclinical development, whereas GNT and PA2 should be considered lead compounds for further optimization strategies aimed at improving selectivity and safety profiles.

Delaine Meireles Gouvêa, Maria Cecília Muniz de Souza Brand, Millena Alves Máximo Vaz et al. · ACS Omega · 0 citations