Biomarkers of the blood-brain barrier and the neurovascular unit and their relationship with cognitive decline and cognitive frailty.
Evidence on biomarkers associated with the blood-brain barrier (BBB) and neurovascular unit (NVU) in CD and CF support vascular and neuroinflammatory mechanisms as early, partially Alzheimer's disease-independent contributors to CD and CF, with significant modification by APOE4 and metabolic comorbidities.