CaMKII monomers are sufficient for GluN2B binding, co-condensation, and synaptic potentiation
SUMMARY Cognitive functions require synaptic plasticity, specifically long-term potentiation (LTP). LTP is thought to require CaMKII binding to the NMDA-type glutamate receptor subunit GluN2B, but this poses a conundrum: Truncated CaMKII monomers (without the hub domain that forms 12meric holoenzymes) fail to bind GluN...