Author

C. M. Vargiu

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Open access Sep 2026

Changes in five cerebrospinal fluid and three plasma Alzheimer’s disease biomarkers across increasing brain amyloid-beta and tau pathology burden

A sequential model of biomarker changes across the Alzheimer’s disease neuropathological continuum is supported, with CSF Aβ42/Aβ40 best reflects low/intermediate Aβ burden, while CSF p-tau markers are more closely related to high Aβ and intermediate tau load.

A. Mastrangelo, Simone Baiardi, Edoardo Ruggeri et al. · Acta Neuropathologica · 0 citations

Open access Jul 2026

Spatial multi-omics identifies early synaptic pruning and context-specific dopaminergic vulnerability in synucleinopathies

It is shown that early complement associated pruning of inhibitory synapses precedes overt α-synuclein aggregation and neuronal loss in prodromal synucleinopathy, indicating disease-context dependent relationships between αSyn pathology and neurodegeneration.

Svenja-Lotta Rumpf, Felix L. Strübing, Karsten Nalbach et al. · Nature Communications · 0 citations