482. Altered GABAb receptor–mediated cortical inhibition in heavy alcohol use: evidence from a pharmaco-TMS study using baclofen
Abstract Background Gamma-aminobutyric acid (GABA) is the principal inhibitory neurotransmitter of the central nervous system, and dysregulation of GABAergic signaling has been consistently implicated in Alcohol Use Disorder (AUD). In particular, metabotropic GABAb receptors (GABAbRs) play a key role in regulating cort...