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Author

C. Morisseau

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2 papers indexed here

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Oct 2026

Chinese yam polysaccharide attenuates DSS-induced ulcerative colitis by modulating gut microbiota and eicosanoid metabolism.

This study investigated the protective mechanisms of Chinese yam polysaccharide (CYP) against dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in mice, focusing on intestinal barrier repair, gut microbiota-mediated effects, and host lipid metabolic regulation. CYP treatment alleviated disease severity and r...

Yu-Shun Qian, Jia-Xin Li, Jin-Zhou Xiao et al. · 0 citations
Open access Aug 2026

Topliss‐Guided Optimization of Acetanilide‐Based Soluble Epoxide Hydrolase Inhibitors: Exploring the Pentafluorosulfanyl Group as a Potency‐Enhancing Motif

Surprisingly, substitution of the trifluoromethyl group of TPPU with a pentafluorosulfanyl substituent restored potency against human sEH, leading to the identification of a promising hit compound and the utility of the underexplored pentafluorosulfanyl group and the TBS strategy for optimizing amide‐based sEH inhibito...

Alba López-Ruiz, Eugènia Pujol, C. Ramos et al. · 0 citations

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